Module 4: When & How to Treat a UTI
- Section 1 provides a discussion of the clinical decision about when to treat a suspected urinary tract infection and the five moments of antibiotic decision-making.
- Section 2 presents basic principles related to initiating treatment, along with guidance about empiric treatment of uncomplicated and complicated urinary tract infection.
- Section 3 reviews opportunities to modify existing antibiotic therapy and reviews antibiotic timeout.
- Section 4 provides an overview of the collaborative role of the pharmacist in antibiotic stewardship, along with sample documents related to a Collaborative Practice Agreement.
Section 1: When to Treat -+
Section 2: How to Treat -+
Section 3: Antibiotic Time Out -+
Section 4: Collaborative Role of the Pharmacist -+
Additional Resources -+
University of Nebraska Urinary Tract Infection and Asymptomatic Bacteriuria Guidance This resource developed by the University of Nebraska Antimicrobial Stewardship Program provides useful information on the selection of antibiotics in patients experiencing a complicated urinary tract infection.
Johns Hopkins ABX Guide: Urinary Tract Infection, Complicated (UTI) This links to recommendations for the treatment of complicated UTI (requires a paid subscription).
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Glomerular Filtration Rate (GFR) Calculator A freely available online GFR calculator that includes adjustment for race and gender. This calculator otherwise only requires resident serum creatinine (mg/dL) and age. A recent weight is not required to provide an estimated GFR.
Cockcroft-Gault Creatinine Clearance Equation (MDCalc) This freely available online calculator that estimates an individual’s creatinine clearance based on their gender, age, weight and serum creatinine (mg/mL).
Reference List-+
- Crnich CJ, Drinka, PJ. Improving the Management of Urinary Tract Infections in Nursing Homes: It’s Time to Stop the Tail From Wagging the Dog. Ann Long Term Care 2014;22(9):32-6.
- Nace DA, Drinka PJ, Crnich CJ. Clinical Uncertainties in the Approach to Long Term Care Residents with Possible Urinary Tract Infection. J Am Med Dir Assoc 2014;15(2):133-9. PMID: 2446120.
- Brown KA, Khanafer N, Daneman N, Fisman DN. Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother 2013 May;57(5):2326-32. doi: 10.1128/AAC.02176-12. PMID: 23478961.
- Tandan M, Cormican M, Vellinga A. Adverse events of fluoroquinolones vs. other antimicrobials prescribed in primary care: A systematic review and meta-analysis of randomized controlled trials. Int J Antimicrob Agents 2018;52:529-40. doi: 10.1016/j.ijantimicag.2018.04.014.
- Daneman N, Lu H, Redelmeier DA. Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study. BMJ Open 2015 Nov 18;5(11):e010077. doi: 10.1136/bmjopen-2015-010077. PMID: 26582407.
- FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together.
- Drekonja DM, Rector TS, Cutting A, Johnson JR. Urinary tract infection in male veterans: treatment patterns and outcomes. JAMA Intern Med 2013 Jan 14;173(1):62-8. doi: 10.1001/2013.jamainternmed.829. PMID: 23212273.
- Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. J Am Med Dir Assoc 2018 Sep;19(9):765-769.e3. doi: 10.1016/j.jamda.2018.05.030. PMID: 30037743.
- Hanlon JT, Perera S, Drinka PJ, Crnich CJ, Schweon SJ, Klein-Fedyshin M, Wessel CB, Saracco S, Anderson G, Mulligan M, Nace DA. The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. J Am Geriatr Soc 2019 Mar;67(3):539-545. doi: 10.1111/jgs.15726. PMID: 30584657.
- University of Nebraska-Urinary Tract Infection and Asymptomatic Bacteriuria Guideline.
- Gupta K, Hooton TM, Miller L; Uncomplicated UTI IDSA Guideline Committee. Managing uncomplicated urinary tract infection--making sense out of resistance data. Clin Infect Dis 2011 Nov;53(10):1041-2. doi: 10.1093/cid/cir637. PMID: 21940416.
- Hossin T, Bahranian M, Taylor L, Nace D, Crnich CJ. Estimating the impact of post-prescribing review on the quality of antibiotic prescribing in skilled nursing facilities. Open Forum Infect Dis 2017; 4(Suppl 1): S160.
- Lee TC, Frenette C, Jayaraman D, Green L, Pilote L. Antibiotic self-stewardship: trainee-led structured antibiotic time-outs to improve antimicrobial use. Ann Intern Med 2014 Nov 18;161(10 Suppl):S53-8. doi: 10.7326/M13-3016. PMID: 25402404.
- Jones M, Butler J, Graber CJ, Glassman P, Samore MH, Pollack LA, Weir C, Goetz MB. Think twice: A cognitive perspective of an antibiotic timeout intervention to improve antibiotic use. J Biomed Inform 2017 Jul;71S:S22-S31. doi:10.1016/j.jbi.2016.06.005. PMID: 27327529.
- CDC Core Elements of Antibiotic Stewardship in Nursing Homes
- 2013 Wisconsin Act 294

